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              <text>Sera Lortye&lt;br /&gt;Joanne P. Will&lt;br /&gt;Loes A. Marquenie&lt;br /&gt;Nick M. Lommerse&lt;br /&gt;Nathalie Faber&lt;br /&gt;Anna E. Goudriaan&lt;br /&gt;Arnoud Arntz&lt;br /&gt;Marleen M. de Waal</text>
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              <text>Lortye, S., Will, J. P., Marquenie, L. A., Lommerse, N. M., Faber, N., Goudriaan, A. E., Arntz, A., &amp;amp; de Waal, M. M. (2025, May). &lt;a href="https://doi.org/10.1111/add.70097"&gt;Effectiveness of treating post-traumatic stress disorder in patients with co-occurring substance use disorder with prolonged exposure, eye movement desensitization and reprocessing or imagery rescripting: A randomized controlled trial.&lt;/a&gt; Addiction. doi:10.1111/add.70097</text>
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              <text>&lt;a href="https://doi.org/10.1111/add.70097"&gt;https://doi.org/10.1111/add.70097&lt;/a&gt;</text>
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                <text>Effectiveness of treating post-traumatic stress disorder in patients with co-occurring substance use disorder with prolonged exposure, eye movement desensitization and reprocessing or imagery rescripting: A randomized controlled trial</text>
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                <text>&lt;strong&gt;Background and aims&lt;/strong&gt;&lt;br /&gt;Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) are highly co-occurring and evidence for the optimal ways of treating PTSD in SUD patients is mixed. Our aim was to compare three different PTSD treatments, each added simultaneously to SUD treatment, with SUD treatment alone in patients with co-occurring SUD-PTSD. These PTSD treatments were: Prolonged Exposure (PE), Eye Movement Desensitization and Reprocessing (EMDR) and Imagery Rescripting (ImRs). &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Design&lt;/strong&gt;&lt;br /&gt;A single-blind 4-arm randomized controlled trial with follow-up at 3 months. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Setting&lt;/strong&gt;&lt;br /&gt;Two addiction treatment centers in the Netherlands, providing intra- and extramural care. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Participants&lt;/strong&gt;&lt;br /&gt;209 patients with SUD and co-morbid PTSD were included [mean age 37.5 (standard deviation, SD = 11.99), female sex = 46.4%, mean Clinically Administered PTSD Scale (CAPS) score = 37.35 (SD = 9.28)]. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Interventions&lt;/strong&gt;&lt;br /&gt;Participants were randomized to either simultaneous SUD + PE (n = 53), SUD + EMDR (n = 50), SUD + ImRs (n = 55) or to SUD treatment only (n = 51), with the active PTSD treatments consisting of 12 sessions each within 3 months. Standard protocols were used. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Measurements&lt;/strong&gt;&lt;br /&gt;The primary outcome was clinician-administered PTSD symptom severity as measured by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (CAPS-5) at 3 month follow-up. Secondary outcomes included loss of PTSD diagnosis, full remission of PSTD and SUD-severity, also recorded at 3 months. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Findings&lt;/strong&gt;&lt;br /&gt;Compared with SUD only, the mean differences in CAPS-5 score were B = -5.41 [95% confidence interval (CI) = 10.88, 0.05, P = 0.052] for SUD + PE, B = -7.97 (95% CI = -13.57, -2.37, P = 0.006) for SUD + EMDR and B = -10.03 (95% CI = -15.29, -4.77, P &amp;lt; 0.001) for SUD + ImRs. When adjusted for baseline covariates, mean differences were B = -5.81 (95% CI = -11.48, -0.15, P = 0.044) for SUD + PE, B = -8.85 (95% CI = -14.60, -3.10, P = 0.003) for SUD + EMDR and B = -10.75 (95% CI = -15.94, -5.56, P = &amp;lt;0.001) for SUD + ImRs. No between-group differences in SUD outcomes were found. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions&lt;/strong&gt;&lt;br /&gt;Among people with co-occurring substance use disorder (SUD) and post-traumatic stress disorder (PTSD), trauma-focused PTSD treatment as add-on to SUD treatment appears to be effective in decreasing PTSD severity compared with manualized SUD only treatment and does not appear to increase SUD severity.</text>
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                <text>Addiction. doi:10.1111/add.70097</text>
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                <text>2025, May</text>
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              <text>&lt;a href="%3A%20https%3A//doi.org/10.1080/20008066.2025.2451478"&gt;https://doi.org/10.1080/20008066.2025.2451478&lt;/a&gt;</text>
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              <text>Rentinck, R. M., van Mourik, R., de Jongh, A., &amp;amp; Matthijssen, S. J. M. A. (2025). &lt;a href="%3A%20https%3A//doi.org/10.1080/20008066.2025.2451478"&gt;Effectiveness of an intensive outpatient treatment programme combining prolonged exposure and EMDR therapy for adolescents and young adults with PTSD in a naturalistic setting&lt;/a&gt;. European Journal of Psychotraumatology, 16(1), 2451478, doi:10.1080/20008066.2025.2451478</text>
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              <text>Elvira M. Rentinck&lt;br /&gt;Rosa van Mourik&lt;br /&gt;Ad de Jongh&lt;br /&gt;Suzy J. M. A. Matthijssen</text>
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                <text>Effectiveness of an intensive outpatient treatment programme combining prolonged exposure and EMDR therapy for adolescents and young adults with PTSD in a naturalistic setting &lt;br /&gt;&lt;br /&gt;Eficacia de un programa de tratamiento intensivo ambulatorio combinando terapias de exposición prolongada y EMDR para adolescentes y adultos jóvenes con TEPT en un encuadre naturalista</text>
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                <text>&lt;strong&gt;Background&lt;/strong&gt; &lt;br /&gt;Psychotherapeutic interventions aimed at treating posttraumatic stress disorder (PTSD) in adolescents and young adults are hampered by high dropout rates. Looking at the results from adult treatments, short, intensive, outpatient treatment programmes may offer a promising alternative, but it has yet to be tested in this young population. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objective&lt;/strong&gt;&lt;br /&gt;To assess the results of a six-day intensive outpatient trauma-focused treatment programme for young individuals (12-25 years) with PTSD. The treatment combined prolonged exposure and EMDR therapy, supplemented with physical activity and the participation of relatives and/or friends. Treatment was performed by a rotating team of therapists. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Methods&lt;/strong&gt; &lt;br /&gt;Seventy-four adolescents and young adults (89% women, mean age = 18.6 years, 36 patients aged 12–17 and 38 patients aged 18-25; SD = 3.1) with PTSD and a minimum of four memories of A-criterion traumatic events participated in the programme. PTSD symptoms, depressive symptoms, and the perceived burden of trauma symptoms were assessed before treatment, at the start and one month after treatment. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt; &lt;br /&gt;Patients showed a significant reduction in PTSD symptoms from pre-treatment to one month after treatment (Cohen’s d = 1.66). Of all patients, 52 (70%) showed a clinically meaningful response, and 48 (65%) no longer met the diagnostic criteria for PTSD one month after treatment. Depressive symptoms also decreased significantly (Cohen’s d = 1.02). The dropout rate was 4% (N = 3). None of the patients experienced an adverse event or worsening of symptoms. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions&lt;/strong&gt; &lt;br /&gt;Results suggest that a short, intensive, outpatient therapy programme combining prolonged exposure, EMDR therapy, physical activity, and participation of relatives and friends, is well-tolerated, and an effective and safe treatment alternative for adolescents and young adults with PTSD due to multiple traumatization.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Antecedentes&lt;/strong&gt; &lt;br /&gt;Las intervenciones psicoterapéuticas destinadas a tratar el trastorno de estrés postraumático (TEPT) en adolescentes y adultos jóvenes se ven obstaculizadas por las altas tasas de abandono. Si se analizan los resultados de los tratamientos para adultos, los programas de tratamiento cortos, intensivos, ambulatorios pueden ser una alternativa promisoria, pero aun no han sido probados en esta población juvenil. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objetivo&lt;/strong&gt; &lt;br /&gt;Evaluar los resultados de un programa de tratamiento centrado en trauma ambulatorio de seis días para personas jóvenes (12-25 años) con TEPT. El tratamiento combino las terapias de exposición prolongada y EMDR, complementada con actividad física y la participación de familiares y/o amigos. El tratamiento fue realizado por un equipo rotativo de terapeutas. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Métodos&lt;/strong&gt; &lt;br /&gt;Participaron en el programa setenta y cuatro adolescentes y adultos jóvenes (89% mujeres, edad media = 18.6, 36 pacientes con edades entre 12–17 y 38 pacientes con edades entre 18-25; DE = 3.1) con TEPT y un mínimo de 4 recuerdos de eventos traumáticos del criterio A. Se evaluaron antes del tratamiento, al inicio y un mes después del tratamiento los síntomas de TEPT, síntomas depresivos y la carga percibida de los síntomas de trauma. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Resultados&lt;/strong&gt;&lt;br /&gt;Los pacientes mostraron una reducción significativa de síntomas de TEPT desde el antes del tratamiento hasta un mes después del tratamiento (d de Cohen = 1.66). De todos los pacientes, 52 (70%) mostraron una respuesta clínicamente significativa y 48 (65%) ya no reunía los criterios diagnósticos de TEPT un mes después del tratamiento. Los síntomas depresivos también disminuyeron significativamente (d de Cohen = 1.02). La tasa de abandono fue de 4% (N = 3). Ninguno de los pacientes experimentó eventos adversos o empeoramiento de síntomas. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusiones&lt;/strong&gt;&lt;br /&gt;Los resultados sugieren que un programa de tratamiento corto, intensivo, ambulatorio que combina terapias de exposición prolongada, EMDR, actividad física, y participación de familiares y amigos es bien tolerado y constituye una alternativa de tratamiento eficaz y segura para adolescentes y adultos jóvenes con TEPT debido a traumas múltiples.</text>
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                <text>European Journal of Psychotraumatology, 16(1), 2451478, doi:10.1080/20008066.2025.2451478</text>
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              <text>Irene Tijsseling &lt;br /&gt;Anna T. van ’t Noordende&lt;br /&gt;Bonne J. H. Zijlstra&lt;br /&gt;Merijn Merbis&lt;br /&gt;Suzanne C. van Veen</text>
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              <text>&lt;a href="http://dx.doi.org/10.1891/EMDR-2023-0051"&gt;http://dx.doi.org/10.1891/EMDR-2023-0051&lt;/a&gt;</text>
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              <text>Tijsseling, I., van 't Noordende, A. T., Zijlstra, B. J. H., Merbis, M., &amp;amp; van Veen S. S. (2024). &lt;a href="http://dx.doi.org/10.1891/EMDR-2023-0051"&gt;The effectiveness and tolerability of an intensive outpatient trauma treatment program for adolescents with PTSD.&lt;/a&gt; Journal of EMDR Practice and Research, 18(2), 68-81. doi:10.1891/EMDR-2023-0051</text>
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                <text>The effectiveness and tolerability of an intensive outpatient trauma treatment program for adolescents with PTSD</text>
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                <text>Following the promising effects of an intensive trauma treatment for adults, the question arises whether adolescents suffering from posttraumatic stress disorder (PTSD) can also benefit from a similar treatment program. The objective of this study was to assess the effectiveness and tolerability of an intensive trauma treatment program combining two evidence-based, trauma-focused therapies— prolonged exposure (PE) and eye movement desensitization and reprocessing (EMDR)—with psychoeducation and physical activity for adolescents suffering from PTSD in an outpatient clinic. We used a multiple-baseline study design. Fifteen adolescents aged 12–18 years old with a Diagnostic and Statistical Manual of Mental Disorders (5th ed.) diagnosis of PTSD were included. Participants were randomized to wait 2, 3, or 4 weeks between the start of baseline and the start of the intervention. In the 2-week intervention period, participants received daily PE, EMDR, and physical activity. The social network of adolescents was involved for support. PTSD symptoms and treatment tolerability were assessed daily. PTSD diagnosis was assessed at baseline and at 1 month and 3 months after completion of treatment. In addition, semistructured interviews were conducted after treatment to determine the tolerability. After treatment, we found a diagnostic PTSD remission of 58%–62% and a decrease in PTSD severity compared with baseline. The effects were maintained at 1-month and 3-month follow-ups. The dropout rate was 13%. Participants reported good treatment tolerability. This study provides initial evidence that an intensive outpatient trauma treatment including PE, EMDR therapy, psychoeducation, and physical activity is effective and tolerable for adolescents with PTSD and is associated with low dropout rates.</text>
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                <text>Skills training followed by either EMDR or narrative therapy for posttraumatic stress disorder in adult survivors of childhood abuse: A randomized controlled trial&lt;br /&gt;&lt;br /&gt;Entrenamiento de habilidades seguido de EMDR o terapia narrativa para el trastorno de estres postraumatico en adultos sobrevivientes de abuso en la infancia: un ensayo controlado aleatorizado</text>
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                <text>&lt;strong&gt;Background&lt;/strong&gt;&lt;br /&gt;Individuals suffering from PTSD following childhood abuse represent a large subgroup of patients attending mental health services. The aim of phase-based treatment is to tailor treatment to the specific needs to childhood abuse survivors with PTSD with a Skills Training in Affective and Interpersonal Regulation (STAIR) phase, in which emotion dysregulation and interpersonal problems are targeted, and a trauma-focused phase.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objective&lt;/strong&gt;&lt;br /&gt;The purpose of this study was to compare STAIR + Eye Movement Desensitization and Reprocessing (EMDR) vs. STAIR + Narrative Therapy (NT) as treatments for PTSD following childhood-onset trauma in a routine clinical setting.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Method&lt;/strong&gt;&lt;br /&gt;Sixty-eight adults were randomly assigned to STAIR/EMDR (8 STAIR-sessions followed by 12 EMDR-sessions) or STAIR/NT (8 STAIR-sessions followed by 12 NT-sessions). Assessments took place at pre-treatment, after each treatment phase and at 3 and 12 months post- intervention follow-up. Primary outcomes were interviewer-rated and self-reported symptom levels of PTSD. Secondary outcomes included symptom levels of depression and disturbances in emotion regulation and interpersonal skills.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;br /&gt;Multilevel analyses in the intent-to-treat sample indicated that patients in both treatments improved substantially on PTSD symptom severity (CAPS: d = 0.81 to 1.29; PDS: d = 1.68 to 2.15), as well as on symptom levels of depression, anxiety, emotion regulation, dissociation and interpersonal skills. Effects increased or were maintained until 12-month follow-up. At mid-treatment, after STAIR, patients in both treatments improved moderately on PTSD symptom severity (PDS: d = 1.68 to 2.15), as well as on symptom levels of depression (BDI: d = .32 to .31). Symptoms of anxiety, emotion dysregulation, interpersonal problems and dissociation were not decreased after STAIR. There were no significant differences between the two conditions on any outcome.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;&lt;br /&gt;PTSD in adult survivors of childhood interpersonal trauma can effectively be treated by phase-based interventions using either EMDR or NT in the trauma-processing phase. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Antecedentes&lt;/strong&gt;&lt;br /&gt;Las personas que sufren de TEPT después de la niñez representan un gran subgrupo de pacientes que asisten a servicios de salud mental en general, así como tambien a servicios especializados para TEPT. El objetivo del tratamiento basado en fases es adaptar el tratamiento a las necesidades específicas de los sobrevivientes de abuso en la infancia con TEPT con una fase de Entrenamiento de Habilidades en Regulación Afectiva e Interpersonal (STAIR por sus siglas en inglés), en la que se aborda la desregulación emocional y los problemas interpersonales y una fase centrada en el trauma, donde tiene lugar el procesamiento de las experiencias traumáticas.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objetivo&lt;/strong&gt;&lt;br /&gt;El propósito de este estudio fue comparar STAIR + Desensibilización y Reprocesamiento por Movimientos Oculares (EMDR) vs. STAIR + Terapia Narrativa (TN) en adultos sobrevivientes de abuso físico y/o sexual en la infancia en un contexto clínico de rutina.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Método&lt;/strong&gt;&lt;br /&gt;Sesenta y ocho adultos fueron asignados aleatoriamente a una de las dos condiciones. En cada condición, el tratamiento consistió en un máximo de 20 sesiones (8 STAIR + 12 EMDR o 8STAIR + 12 TN). Se realizaron evaluaciones ciegas antes del tratamiento, después de la fase STAIR, 2 semanas después de la última sesión (ej. Post tratamiento), y 3 y 12 meses después del final del tratamiento. Las medidas de resultado primarias fueron los niveles de síntomas de TEPT calificados por el entrevistador y auto-reportadas. Las medidas de resultado secundarias incluyeron niveles de depresión y alteraciones en la regulación emocional y habilidades interpersonales.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Resultados&lt;/strong&gt;&lt;br /&gt;Los análisis multinivel en la muestra por intención de tratar indicaron que los pacientes mejoraban sustancialmente con ambos tratamientos en la gravedad de los síntomas de TEPT (CAPS: d = 0.81 a 1.29; PDS: d = 1.68 a 2.15), así como tambien en los niveles de síntomas de depresión, ansiedad, regulación emocional, disociación y habilidades interpersonales. Los efectos aumentaron o se mantuvieron hasta los 12 meses de seguimiento. A la mitad del tratamiento, después del STAIR, los pacientes en ambos tratamientos mejoraron moderadamente en la gravedad de los síntomas de TEPT (PDS: d = 1.68 a 2.15), así como tambien en los niveles de síntomas de depresión (BDI: d = .32 a .31).</text>
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              <text>Klaeth, J. R., Jensen, A. G., Auren, T. J. B., &amp;amp; Solem, S. (2024). &lt;a href="https://doi.org/10.1186/s12888-024-05656-9"&gt;12-month follow-up of intensive outpatient treatment for PTSD combining prolonged exposure therapy, EMDR and physical activity.&lt;/a&gt; BMC Psychiatry, 24, 255. doi:10.1186/s12888-024-05656-9</text>
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                <text>&lt;strong&gt;Background&lt;/strong&gt; &lt;br /&gt;Preliminary evidence shows promising treatment outcomes at short-term follow-up for intensive posttraumatic stress disorder (PTSD) treatment, but long-term follow-up studies are sparse. This study is a sequel to a previous pilot study and open trial, set out to investigate treatment outcomes at 12-month follow-up for outpatients completing an 8-day intensive treatment for PTSD. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Methods&lt;/strong&gt; &lt;br /&gt;All patients were diagnosed with PTSD and had multiple previous psychotherapy attempts (M = 3.1). Patients were assessed at pre-treatment, post-treatment, 3- and 12-month follow-up. Of 35 treated patients, 32 (91.4%) attended the long-term follow-up assessment. The treatment programme combined prolonged exposure therapy, eye movement desensitization and reprocessing, and physical activity. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt; &lt;br /&gt;The effect sizes indicated large reductions in symptoms of PTSD, depression, anxiety, interpersonal problems, and well-being. Changes in functioning showed a small-medium effect. Results were stable across the follow-up period. The treatment response rates showed that 46–60% of patients achieved recovery with respect to PTSD symptoms, and that 44–48% no longer met diagnostic criteria for PTSD. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions&lt;/strong&gt; &lt;br /&gt;Time-limited and concentrated outpatient treatment for PTSD can yield large and enduring positive outcomes. Controlled trials are needed to establish relative efficacy.</text>
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              <text>Matthijssen, J. M. A., &amp;amp; Menses, S. D. F. (2024, April). Case report: 'Intensive online trauma treatment combining prolonged exposure and EMDR 2.0 in a patient with severe and chronic PTSD.' Frontiers in Psychiatry, 15. doi:10.3389/fpsyt.2024.1370358</text>
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                <text>&lt;strong&gt;Introduction&lt;/strong&gt;&lt;br /&gt;Short and intensive trauma treatment programs seem promising in treating post-traumatic stress disorder (PTSD). However, little is known about the effects performing these types of intensive treatment programs online. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Method&lt;/strong&gt;&lt;br /&gt;At the Altrecht Academic Anxiety Centre, an in person intensive trauma focused treatment of six days (three consecutive days in two weeks) was altered into a fully online treatment. A treatment day consisted of 90 minutes of prolonged exposure, 60 minutes of exercise, 90 minutes of Eye Movement Desensitization and Reprocessing (EMDR) 2.0 and 60 minutes of psychoeducation. Mary, a patient diagnosed with chronic and severe PTSD, chronic depressive disorder (single episode, moderate to severe), a panic disorder, and an other specified personality disorder was the first patient to take part in this intensive online trauma treatment. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;br /&gt;Mary reached full remission of PTSD. The PTSD symptoms (measured on both the clinician-administered PTSD scale for DSM-5, CAPS-5 and The PTSD Checklist for DSM-5, PCL-5) showed maximum improvement and were completely absent during one month and six month follow-up. Moreover, she no longer suffered from severe depressive symptoms and did not report any general psychiatric symptoms (measured with the Beck Depression Inventory version 2, BDI-II and the Brief Symptom Inventory, BSI). &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;&lt;br /&gt;In conclusion, the case-report demonstrates that intensive trauma treatment online was successful in this specific case, thereby being a ‘proof of concept’ that intensive trauma treatment online is feasible. It might be promising for patients with severe and chronic PTSD and comorbid psychiatric disorders. However, further research must show if the results of this specific case can be translated to other patients with severe and chronic PTSD and comorbid psychiatric disorders.</text>
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                <text>This study aims to compare the efficacy and efficiency of EMDR and prolonged exposure (PE) in the treatment of posttraumatic stress disorder (PTSD) in adults. Both interventions are standardized treatments for PTSD, however, each intervention’s mechanism of action are different, with EMDR being classified as a bottom-up psychotherapy model and PE being classified as a top-down psychotherapy model. A second aim of this study is to investigate whether differences in treatment response to EMDR compared to PE is moderated by interoception, a person’s ability to be aware of their internal states of their body. To accomplish these goals, a randomized controlled trial will be completed, with participants (adults over 18 meeting DSM-V criteria for diagnosis of PTSD) being randomized to either receive EMDR, PE, or a wait-list control for 3 months (weekly sessions, 12 sessions total). Symptoms will be assessed by treatment-blind assessors at posttreatment, and at 3-and 6-months follow-up. • EMDR and PE are both recommended treatments for PTSD by the International Society of Traumatic Stress Studies (ISTSS). While previous studies have demonstrated both EMDR and PE were effective in PTSD symptom reduction in comparison to minimal intervention, they also indicated EMDR was more efficient than PE in terms of total exposure time to traumatic memories during and between sessions; the number of trauma memories processed over the course of therapy; and time taken to process the primary trauma memory (McGuire Stanbury et al., 2020)</text>
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                <text>Eye movement desensitization and reprocessing (EMDR) therapy is a well established therapeutic method to treat post-traumatic stress disorder (PTSD). However, how EMDR exerts its therapeutic action has been studied in many researches but still needs to be completely understood. This is in part due to a limited knowledge of the neurobiological mechanisms underlying EMDR, and in part to our incomplete understanding of PTSD. In order to model PTSD we used a biologically inspired computational model based on firing rate units, encompassing cortex, hippocampus and amygdala. Through the modulation of its parameters we fitted real data from patients treated with EMDR or classical exposure therapy. This allowed us to gain insights into PTSD mechanisms and to investigate how EMDR achieves trauma remission.</text>
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                <text>During the global outbreak of COVID-19, psychiatric patients reported increased symptoms and poorer access to services and support. Psychical measures aimed at reducing contagion, forced clinicians to look for distant-delivered PTSD treatments. So far, few studies have conducted head-to-head comparison between of traditional in-person treatments and telehealth-delivered treatments. The aim of this study was to determine the effectiveness of an online intensive trauma-focused treatment programme over 6 days for individuals suffering from posttraumatic stress disorder (PTSD). In addition, this non-randomized study evaluated the effectiveness of the treatment online-delivered in comparison to face-to-face delivered. Effects were monitored up to 6-month after treatment. Treatment was provided for a total of 159 patients (145 face-to-face treatment; 14 online treatment) and consisted of daily sessions of prolonged exposure (PE) and eye movement desensitization and reprocessing (EMDR) therapy (12 sessions in total), physical activity and psycho-education. PTSD symptom severity was assessed by both clinician-rated (Clinician Administered PTSD Scale CAPS) and self-report (PTSD Checklist PCL-5; Visual Analog Scales VAS). Depression and psychopathology symptoms were assessed by self-report (Brief Symptom Inventory BSI; Beck Depression Inventory BDI-II). From screening to 4-week and 6-month follow up, patients showed significant improvements in PTSD symptoms. From pre-treatment to 1-week, 4-week and 6 month-follow up, patients showed significant improvements in depression- and psychopathology symptoms. More than half of the patients lost their PTSD diagnoses. In comparison to the face-to-face treatment group, patients in the online treatment group showed equal effect. These results indicate that an online-delivered intensive treatment program combining PE, EMDR combining PE, EMDR, physical activity and psycho-education is a potentially effective treatment for patients suffering from PTSD.</text>
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                <text>Intensive outpatient treatment for PTSD: a pilot feasibility study combining prolonged exposure therapy, EMDR, physical activity, and psychoeducation &lt;br /&gt;&lt;br /&gt;Tratamiento ambulatorio intensivo para el TEPT: Un estudio piloto de viabilidad que combina terapia de exposición prolongada, EMDR, actividad física y psicoeducación PTSD&lt;br /&gt;&lt;br /&gt;的强化门诊治疗:结合延长暴露疗法, EMDR, 体育锻炼和心理教育的试点可行性研究</text>
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                <text>&lt;strong&gt;Background&lt;/strong&gt;&lt;br /&gt;Intensive treatment could be effective for patients with post-traumatic stress disorder (PTSD). Objective: The aim of the study was to test the feasibility of an 8-day (2-week) intensive outpatient treatment for PTSD. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Method&lt;/strong&gt;&lt;br /&gt;Treatment each day consisted of individual Prolonged Exposure (PE), Eye Movement Desensitization and Reprocessing (EMDR), and psychoeducation and physical activity in groups. Patients met different therapists from session to session. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;br /&gt;Six patients started and completed treatment. Levels of attendance of sessions was high. Patients reported that they were satisfied with the treatment, describing it as emotionally taxing, but meaningful. Therapists also described several positive aspects of the treatment format. There were large reductions in PTSD symptoms. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions&lt;/strong&gt;&lt;br /&gt;Given these promising, but preliminary findings on the programme’s feasibility, future research should investigate this treatment format using larger samples and controlled designs.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Antecedentes&lt;/strong&gt;&lt;br /&gt;El tratamiento intensivo podría ser eficaz para los pacientes con trastorno de estrés postraumático (TEPT).&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objetivo&lt;/strong&gt;&lt;br /&gt;El objetivo del estudio fue comprobar la viabilidad de un tratamiento intensivo de 8 días (2 semanas) en régimen ambulatorio para el TEPT.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Método&lt;/strong&gt;&lt;br /&gt;El tratamiento diario consistió en forma individual la exposición prolongada (EP), desensibilización y reprocesamiento por movimientos oculares (EMDR), y en grupo la psicoeducación y actividad física. Los pacientes se reunían con diferentes terapeutas de una sesión a otra.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Resultados&lt;/strong&gt;&lt;br /&gt;Seis pacientes iniciaron y completaron el tratamiento. El nivel de asistencia a las sesiones fue alto. Los pacientes informaron que estaban satisfechos con el tratamiento, describiéndolo como emocionalmente agotador, pero significativo. Los terapeutas también describieron varios aspectos positivos del formato del tratamiento. Hubo grandes reducciones en los síntomas del TEPT.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusiones&lt;/strong&gt;&lt;br /&gt;Teniendo en cuenta estos resultados prometedores, pero preliminares, sobre la viabilidad del programa, la investigación futura debería investigar este formato de tratamiento utilizando muestras más grandes y diseños controlados.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;背景&lt;/strong&gt;&lt;br /&gt;强化治疗可能对创伤后应激障碍 (PTSD) 患者有效° &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;目的&lt;/strong&gt;&lt;br /&gt;本研究旨在考查为期8天 (2周) 的PTSD强化门诊治疗的可行性°&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;方法&lt;/strong&gt;&lt;br /&gt;每天的治疗包括个体的延长暴露 (PE), 眼动脱敏和再加工 (EMDR) 以及心理教育和体育 锻炼° 患者在每次治疗时会遇到不同的治疗师° 结果: 6例患者开始并完成了治疗° 治疗参与率很高° 患者报告说他们对治疗很满意, 称其在情&lt;br /&gt;感上很费力, 但很有意义° 治疗师还描述了治疗形式的几个积极方面° PTSD症状明显减轻° &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;结论&lt;/strong&gt;&lt;br /&gt;鉴于此治疗计划的这些有希望但初步的发现, 未来研究应使用更大样本和对照设计来 研究这种治疗方式°</text>
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              <text>van Pelt, Y., Fokkema, P., de Roos, C., &amp;amp; de Jongh, A.(2021). &lt;a href="https://doi.org/10.1080/20008198.2021.1917876"&gt;Effectiveness of an intensive treatment programme combining prolonged exposure and EMDR therapy for adolescents suffering from severe post-traumatic stress disorder.&lt;/a&gt; European Journal of Psychotraumatology, 12(1), 1917876. doi:10.1080/20008198.2021.1917876</text>
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                <text>&lt;strong&gt;Background&lt;/strong&gt;&lt;br /&gt;Following promising effects of an intensive trauma treatment for adults, the question arises whether adolescents who suffer from severe post-traumatic stress disorder (PTSD) can also profit from a similar treatment programme. Objective: To assess the effectiveness of an intensive trauma-focused treatment programme combining two evidence-based trauma-focused therapies and physical activities for adolescents suffering from severe PTSD. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Method&lt;/strong&gt;&lt;br /&gt;Treatment consisted of daily sessions of prolonged exposure (PE) therapy and eye movement desensitization and reprocessing (EMDR) therapy supplemented with physical activity (13 days on average). All patients (N = 27; 96.3% women, mean age = 16.1 years; SD = 1.3) had been exposed to one or more (interpersonal) traumatic events. Twenty-two of them (81.5%) also fulfilled the diagnostic criteria of a comorbid psychiatric disorder (mean number of comorbid disorders = 2.22). The majority of patients were referred because previous treatment was difficult or complications were expected to occur. Severity of PTSD symptoms and presence of a PTSD diagnostic status were assessed using the Dutch version of the CAPSCA IV at baseline, post-treatment and at 3-month follow-up. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;br /&gt;CAPS-CA IV scores decreased significantly from pre- to post-treatment (Cohen’s d = 1.39). Of all patients 81.5% (n = 22) showed a clinically meaningful response, of whom 63% (n = 17) no longer fulfilled the diagnostic criteria of PTSD at post-treatment as established with the CAPS-CA IV. The results were maintained at 3-month follow-up. During treatment, neither adverse events nor dropout occurred. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions&lt;/strong&gt;&lt;br /&gt;The results suggest that an intensive trauma-focused treatment programme combining prolonged exposure, EMDR therapy, and physical activity can be an effective and safe treatment for adolescents suffering from severe PTSD and multiple comorbid psychiatric disorders.</text>
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              <text>&lt;a href="http://dx.doi.org/10.1891/1933-3196.14.1.2"&gt;http://dx.doi.org/10.1891/1933-3196.14.1.2&lt;/a&gt;</text>
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              <text>Stanbury, T. M. M., Drummond, P. D., Laugharne, J., Kullack, C., &amp;amp; Lee, C. W. (2020). &lt;a href="http://dx.doi.org/10.1891/1933-3196.14.1.2"&gt;Comparative efficiency of EMDR and prolonged exposure in treating posttraumatic stress disorder: A randomized trial.&lt;/a&gt; Journal of EMDR Practice and Research, 14(1), 1-12. doi:10.1891/1933-3196.14.1.2</text>
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                <text>The comparative treatment efficiency of eye movement desensitization and reprocessing (EMDR) therapy and prolonged exposure (PE) therapy for the treatment of posttraumatic stress disorder (PTSD) was tested for 20 participants diagnosed with PTSD. Efficiency was operationalized as the total exposure time to traumatic memories during and between sessions; the number of trauma memories processed over the course of therapy; how many sessions were required to resolve the primary trauma; and lower subjective units of disturbance (SUD) levels after the initial treatment session. Participants were randomized to each condition and received 12 90-minute sessions of therapy over 6 weeks. Symptoms were assessed by treatment-blind assessors at posttreatment, and at 3 and 6 months follow-up. Results demonstrated a significant decrease in symptoms posttreatment for PTSD (d = .64), depression (d = .46), anxiety (d = .52) and stress (d = .57) for both groups, which was maintained at 3 months. At 6 months there was a small increase in symptoms compared to the 3-month time point on the Clinician-Administered PTSD Scale (CAPS) but no significant change in any self-report symptoms EMDR was significantly more efficient than PE. EMDR participants had less total exposure time to traumatic memories when homework hours were included (d = .66), reported lower SUD scores after the first session (d = .45), required fewer sessions for the target memory to decrease to near zero distress levels (d = .84), and processed more traumatic memories.</text>
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                <text>Journal of EMDR Practice and Research, 14(1), 1-12. doi:10.1891/1933-3196.14.1.2</text>
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              <text>Paul A. J. M. de Bont&lt;br /&gt;Berber M. van der Vleugel&lt;br /&gt;David P. G. van den Berg&lt;br /&gt;Carlijn de Roos&lt;br /&gt;Joran Lokkerbol&lt;br /&gt;Filip Smit&lt;br /&gt;Ad de Jongh&lt;br /&gt;Mark van der Gaag&lt;br /&gt;Agnes van Minnen</text>
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              <text>de Bont, P. A. J. M., van der Vleugel, B. M., van den Berg, D. P. G., de Roos, C., Lokkerbol, J., Smit, F., de Jongh, A., van der Gaag, M., &amp;amp; van Minnen, A. (2019, January). &lt;a href="https://doi.org/10.1080/20008198.2018.1565032"&gt;Health-economic benefits of treating trauma in psychosis.&lt;/a&gt; European Journal Of Psychotraumatology, 10(1). doi:10.1080/20008198.2018.1565032.</text>
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              <text>&lt;a href="https://doi.org/10.1080/20008198.2018.1565032"&gt;https://doi.org/10.1080/20008198.2018.1565032&lt;/a&gt;</text>
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                <text>Health-economic benefits of treating trauma in psychosis</text>
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                <text>&lt;strong&gt;Background:&lt;/strong&gt; &lt;br /&gt;Co-occurrence of posttraumatic stress disorder (PTSD) in psychosis (estimated as 12%) raises personal suffering and societal costs. Health-economic studies on PTSD treatments in patients with a diagnosis of a psychotic disorder have not yet been conducted, but are needed for guideline development and implementation. This study aims to analyse the cost-effectiveness of guideline PTSD therapies in patients with a psychotic disorder. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Methods:&lt;/strong&gt; &lt;br /&gt;This health-economic evaluation alongside a randomized controlled trial included 155 patients with a psychotic disorder in care as usual (CAU), with comorbid PTSD. Participants received eye movement desensitization and reprocessing (EMDR) (n = 55), prolonged exposure (PE) (n = 53) or waiting list (WL) (n = 47) with masked assessments at baseline (T0) and at the two-month (post-treatment, T2) and six-month follow-up (T6). Costs were calculated using the TiC-P interview for assessing healthcare consumption and productivity losses. Incremental cost-effectiveness ratios and economic acceptability were calculated for quality-adjusted life years (EQ-5D-3L-based QALYs) and PTSD 'Loss of diagnosis' (LoD, CAPS). &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; &lt;br /&gt;Compared to WL, costs were lower in EMDR (-€1410) and PE (-€501) per patient per six months. In addition, EMDR (robust SE 0.024, t = 2.14, p = .035) and PE (robust SE 0.024, t = 2.14, p = .035) yielded a 0.052 and 0.051 incremental QALY gain, respectively, as well as 26% greater probability for LoD following EMDR (robust SE = 0.096, z = 2.66, p = .008) and 22% following PE (robust SE 0.098, z = 2.28, p = .023). Acceptability curves indicate high probabilities of PTSD treatments being the better economic choice. Sensitivity analyses corroborated these outcomes. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;br /&gt;Adding PTSD treatment to CAU for individuals with psychosis and PTSD seem to yield better health and less PTSD at lower costs, which argues for implementation..</text>
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                <text>European Journal Of Psychotraumatology, 10(1). doi:10.1080/20008198.2018.1565032.</text>
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              <text>Mark van der Gaag &lt;br /&gt;Berber van der Vleugel &lt;br /&gt;Paul de Bont &lt;br /&gt;David van den Berg &lt;br /&gt;Ad de Jongh &lt;br /&gt;Agnes van Minnen</text>
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              <text>van der Gaag, van der Vleugel, de Bont, P., van den Berg, D., de Jongh, A., &amp;amp; van Minnen, A. (2014, April). The results of eye movement desensitization and reprocessing and prolonged exposure in patients with posttraumatic stress disorder and chronic psychotic disorder. Schizophrenia, 153, S74-S75</text>
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                <text>The results of eye movement desensitization and reprocessing and prolonged exposure in patients with posttraumatic stress disorder and chronic psychotic disorder</text>
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              <text>&lt;a href="https://doi.org/10.1080/20008198.2018.1487225"&gt;https://doi.org/10.1080/20008198.2018.1487225&lt;/a&gt;</text>
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              <text>van Woudenberg, C., Voorendonk, E. M., Bongaerts, H.,  Zoet, H. A.,  Verhagen, M., Lee, C. W., A., Minnen, A. V.,  &amp;amp; de Jongh, A. (2018). &lt;a href="https://doi.org/10.1080/20008198.2018.1487225"&gt;Effectiveness of an intensive treatmentprogramme combining prolonged exposure and eye movement desensitization and reprocessingfor severe post-traumatic stress disorder.&lt;/a&gt; European Journal of Psychotraumatology, 9(1). 1487225,DOI: 10.1080/20008198.2018.1487225</text>
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              <text>Clair Van Woudenberg&lt;br /&gt;Eline M. Voorendonk&lt;br /&gt;Hannelies Bongaerts&lt;br /&gt;Homen A. Zoet&lt;br /&gt; Marije Verhagen&lt;br /&gt;Christopher W. Lee&lt;br /&gt;Agnes V. Minnen &lt;br /&gt;Ad de Jongh</text>
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                <text>Effectiveness of an intensive treatment programme combining prolonged exposure and eye movement desensitization and reprocessing for severe post-traumatic stress disorder&lt;br /&gt;&lt;p align="left"&gt;La efectividad de un programa de tratamiento intensivo combinando exposición prolongada y emdr para trastorno de estrés postraumático severo (TEPT)&lt;/p&gt;
&lt;p&gt;一个结合延长暴露和EMDR的强化治疗方案对重度创伤后应激障碍（PTSD）的治疗有效性&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Background:&lt;/strong&gt; &lt;br /&gt;There is room for improvement regarding the treatment of severe post-traumatic stress disorder (PTSD). Intensifying treatment to increase patient retention is a promising development. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;br /&gt;The aim of this study was to determine the effectiveness of an intensive trauma-focused treatment programme over 8 days for individuals suffering from severe PTSD. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Method:&lt;/strong&gt; &lt;br /&gt;Treatment was provided for 347 PTSD patients (70% women; mean age = 38.32 years, SD = 11.69) and consisted of daily sessions of prolonged exposure and eye movement desensitization and reprocessing (EMDR) therapy (16 sessions in total), physical activity, and psycho-education. All participants had experienced multiple traumas, including sexual abuse (74.4%), and suffered from multiple comorbidities (e.g. 87.5% had a mood disorder). Suicidal ideation was frequent (73.9%). PTSD symptom severity was assessed by both clinician-rated [Clinician Administered PTSD Scale (CAPS)] and self-report [PTSD Symptom Scale Self Report (PSS-SR) and Impact of Event Scale (IES)] inventories. For a subsample (n = 109), follow-up data at 6 months were available. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; &lt;br /&gt;A significant decline in symptom severity was found (e.g. CAPS intention-to-treat sample Cohen’s d = 1.64). At post-treatment, 82.9% showed a clinically meaningful response and 54.9% a loss of diagnosis. Dropout was very low (2.3%). &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;br /&gt;Intensive trauma-focused treatment programmes including prolonged exposure, EMDR therapy, and physical activity can be effective for patients suffering from severe PTSD and are associated with low dropout rates.
&lt;p&gt;&lt;strong&gt;Antecedentes:&lt;/strong&gt; &lt;br /&gt;Hay un margen de mejora con respecto al tratamiento del trastorno de estrés postraumático severo (TEPT). Intensificar el tratamiento para aumentar la retención de paciente es un desarrollo prometedor.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Objetivo:&lt;/strong&gt; &lt;br /&gt;Determinar la efectividad de un programa de tratamiento intensivo centrado en trauma durante 8 días para personas que presentan TEPT severo.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Método:&lt;/strong&gt; &lt;br /&gt;Se proporcionó tratamiento a 347 pacientes con TEPT (70,0% mujeres, edad media = 38,32 años, DE = 11,69) y consistió en sesiones diarias de exposición prolongada y terapia EMDR (16 sesiones en total), actividad física, y psico-educación. Todos los participantes habían experimentado múltiples traumas, incluido abuso sexual (74,4%), y padecían múltiples comorbilidades (por ejemplo, 87,5% trastorno anímico). La ideación suicida fue frecuente (73,9%). La gravedad de los síntomas de TEPT fue evaluada tanto por el clínico con inventarios calificados (CAPS) como por auto-reporte (PSS-SR y IES). Para una submuestra (N=109) se dispuso de datos de seguimiento a los seis meses.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Resultados:&lt;/strong&gt; &lt;br /&gt;Se encontró una disminución significativa en la gravedad de los síntomas (por ejemplo, en la muestra CAPS ITT d = 1,64 de Cohen). En el post tratamiento, el 82,9% mostró una respuesta clínicamente significativa y el 54,9% una pérdida del diagnóstico. El abandono fue muy bajo (2,3%).&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Conclusiones:&lt;/strong&gt; &lt;br /&gt;Los programas intensivos de tratamientos centrados en trauma, incluido la terapia de exposición prolongada, la terapia EMDR y la actividad física, pueden ser efectivos para los pacientes que sufren de trastorno de estrés postraumático severo y se asocian con bajas tasas de abandono.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;背景：&lt;/strong&gt;&lt;br /&gt;对重度创伤后应激障碍（PTSD）的治疗还有待改进。有希望通过加强治疗来增加病 人保留率。 目标：确认强化创伤中心治疗方案对重度创伤后应激障碍患者在8天以内的有效性。&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;方法：&lt;/strong&gt;&lt;br /&gt;为347名PTSD患者（70.0％女性，平均年龄38.32岁，SD = 11.69）提供治疗，包括 每天进行的延长暴露和EMDR治疗（总共16次）、体力劳动和心理教育。所有参与者都经 历过多次创伤，包括性虐待（74.4％），并患有多种合并症 例如87.5％有情绪障碍）。 自杀意念频繁出现（73.9％）。同时使用临床医生评分（CAPS）和自我报告（PSS-SR和 IES）的工具评估PTSD症状的严重程度。六个月后搜集了一个子样本（N = 109）的追踪 数据。&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;结果：&lt;/strong&gt;&lt;br /&gt;症状的严重程度显著下降（例如，CAPS ITT-样本Cohen’s d = 1.64）。治疗后82.9％ 表现出有临床意义的反应，54.9％不再符合诊断标准。脱落率非常低（2.3％）。 结论：延长暴露、EMDR治疗和体力活动等强化创伤治疗计划对于患有重度创伤后应激障 碍的病人有效，并有较低的脱落率。&lt;/p&gt;</text>
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              <text>Wagermans, A., van Minnen, A., Sleijpen, M., &amp;amp; de Jongh, A.  (2018, February). &lt;span class="cit"&gt;&lt;span&gt;&lt;a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804725/"&gt;The impact of childhood sexual abuse on the outcome of intensive trauma-focused treatment for PTSD. &lt;/a&gt;European Journal of Psychotraumatol&lt;/span&gt;ogy, 9(1), 430962. &lt;span class="doi" style="white-space:nowrap;"&gt;doi:10.1080/20008198.2018.1430962&lt;/span&gt;&lt;/span&gt;</text>
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                <text>The impact of childhood sexual abuse on the outcome of intensive trauma-focused treatment for PTSD</text>
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                <text>&lt;strong&gt;Background:&lt;/strong&gt; &lt;br /&gt;It is assumed that PTSD patients with a history of childhood sexual abuse benefit less from trauma-focused treatment than those without such a history. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;br /&gt;To test whether the presence of a history of childhood sexual abuse has a negative effect on the outcome of intensive trauma-focused PTSD treatment. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Method:&lt;/strong&gt; &lt;br /&gt;PTSD patients, 83% of whom suffered from severe PTSD, took part in a therapy programme consisting of 2 × 4 consecutive days of Prolonged Exposure (PE) and EMDR therapy (eight of each). In between sessions, patients participated in sport activities and psycho-education sessions. No prior stabilization phase was implemented. PTSD symptom scores of clinician-administered and self-administered measures were analysed using the data of 165 consecutive patients. Pre-post differences were compared between four trauma groups; patients with a history of childhood sexual abuse before age 12 (CSA), adolescent sexual abuse (ASA; i.e. sexual abuse between 12 and 18 years of age), sexual abuse (SA) at age 18 and over, or no history of sexual abuse (NSA). &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; &lt;br /&gt;Large effect sizes were achieved for PTSD symptom reduction for all trauma groups (Cohen’s d = 1.52–2.09). For the Clinical Administered PTSD Scale (CAPS) and the Impact of Event Scale (IES), no differences in treatment outcome were found between the trauma (age) groups. For the PTSD Symptom Scale Self Report (PSS-SR), there were no differences except for one small effect between CSA and NSA. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;br /&gt;The results do not support the hypothesis that the presence of a history of childhood sexual abuse has a detrimental impact on the outcome of first-line (intensive) trauma-focused treatments for PTSD.</text>
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                <text>European Journal of Psychotraumatology, 9(1), 430962. doi:10.1080/20008198.2018.1430962</text>
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              <text>&lt;a href="http://www.madinamerica.com/2015/05/desensitization-therapies-show-promise-for-treating-ptsd-and-psychosis/"&gt;http://www.madinamerica.com/2015/05/desensitization-therapies-show-promise-for-treating-ptsd-and-psychosis/&lt;/a&gt;</text>
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                <text>Medscape Medical News summarized that "those who received PE or EMDR for 8 weeks had a greater reduction in trauma symptoms and were more likely to achieve 'loss of diagnosis' compared with wait-listed participants. In addition, the PE group was more likely than the wait-listed group to gain full remission from PTSD."</text>
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              <text>Schnyder, U. (2014, December). &lt;a href="http://www.ejpt.net/index.php/ejpt/article/view/26520"&gt;Treating intrusions, promoting resilience: An overview of therapies for trauma-related psychological disorders&lt;/a&gt;. European Journal of Psychotraumatology, 5, 26520</text>
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              <text>&lt;a href="http://www.ejpt.net/index.php/ejpt/article/view/26520"&gt;http://www.ejpt.net/index.php/ejpt/article/view/26520&lt;/a&gt;</text>
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                <text>The efficacy of psychotherapeutic approaches in the treatment of posttraumatic stress disorder (PTSD) can be regarded as empirically demonstrated. Overall, effect sizes appear to be higher for psychotherapy than for medication. Many well-controlled trials with a mixed variety of trauma survivors have demonstrated that trauma-focused cognitive-behavioral therapy (TF-CBT) is effective in treating PTSD. Prolonged exposure therapy (PE) is currently seen as the treatment with the strongest evidence for its efficacy. Cognitive therapy (CT) and cognitive processing therapy (CPT), with their stronger emphasis on cognitive techniques, and Eye Movement Desensitization and Reprocessing (EMDR) seem equally effective. More recent developments include brief eclectic psychotherapy for PTSD (BEPP) and narrative exposure therapy (NET). Emerging evidence shows that TF-CBT can successfully be applied in PTSD patients suffering from severe comorbidities such as borderline personality disorder or substance abuse disorder (Schnyder &amp;amp; Cloitre, 2015). There is also a trend towards developing ‘‘mini-interventions,’’ that is, short modules tailored to approach specific problems. Moreover, evidence-based approaches should be complemented by interventions that aim at promoting human resilience to stress. Finally, given the globalization of our societies (Schnyder, 2013), culture-sensitive psychotherapists should try to understand the cultural components of a patient’s illness and help-seeking behaviors, as well as their expectations with regard to treatment.</text>
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                <text>European Journal of Psychotraumatology, 5, 26520</text>
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        <name>NET</name>
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        <name>PE</name>
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        <name>Trauma</name>
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              <text>David P. G. van den Berg&lt;br /&gt;Paul A. J. M. de Bont&lt;br /&gt;Berber M. van der Vleugel&lt;br /&gt;Carlijn de Roos&lt;br /&gt;Ad de Jongh&lt;br /&gt;Agnes Van Minnen&lt;br /&gt;Mark van der Gaag</text>
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              <text>van den Berg, D. P. G., de Bont, P. A. J. M., van der Vleugel, B. M., de Roos, C., de Jongh, A., van Minnen, A., &amp;amp; van der Gaag, M. (2015).  &lt;a href="http://dx.doi.org/10.1001/jamapsychiatry.2014.2637"&gt;Prolonged exposure vs eye movement desensitization and reprocessing vs waiting list for posttraumatic stress disorder in patients with a psychotic disorder: A randomized clinical trial&lt;/a&gt;. Journal of the American Medical Association Psychiatry, 72(3), 259-267. doi:10.1001/jamapsychiatry.2014.2637</text>
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              <text>&lt;a href="http://dx.doi.org/10.1001/jamapsychiatry.2014.2637"&gt;http://dx.doi.org/10.1001/jamapsychiatry.2014.2637&lt;/a&gt;</text>
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                <text>Prolonged exposure vs eye movement desensitization and reprocessing vs waiting list for posttraumatic stress disorder in patients with a psychotic disorder: A randomized clinical trial</text>
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                <text>Importance:&lt;br /&gt;The efficacy of posttraumatic stress disorder (PTSD) treatments in psychosis has not been examined in a randomized clinical trial to our knowledge. Psychosis is an exclusion criterion in most PTSD trials. OBJECTIVE To examine the efficacy and safety of prolonged exposure (PE) therapy and eye movement desensitization and reprocessing (EMDR) therapy in patients with psychotic disorders and comorbid PTSD. &lt;br /&gt;&lt;br /&gt;Design, Setting, Participants:&lt;br /&gt;A single-blind randomized clinical trial with 3 arms (N = 155), including PE therapy, EMDR therapy, and waiting list (WL) of 13 outpatient mental health services among patients with a lifetime psychotic disorder and current chronic PTSD. Baseline, posttreatment, and 6-month follow-up assessments were made. &lt;br /&gt;&lt;br /&gt;Interventions:&lt;br /&gt; Participants were randomized to receive 8 weekly 90-minute sessions of PE (n = 53), EMDR (n = 55), or WL (n = 47). Standard protocols were used, and treatment was not preceded by stabilizing psychotherapeutic interventions. &lt;br /&gt;&lt;br /&gt;Main Outcomes and Measures:&lt;br /&gt; Clinician-rated severity of PTSD symptoms, PTSD diagnosis, and full remission (on the Clinician-Administered PTSD Scale) were primary outcomes. Self-reported PTSD symptoms and posttraumatic cognitions were secondary outcomes. &lt;br /&gt;&lt;br /&gt;Results:&lt;br /&gt; Data were analyzed as intent to treat with linear mixed models and generalized estimating equations. Participants in the PE and EMDR conditions showed a greater reduction of PTSD symptoms than those in the WL condition. Between-group effect sizes were 0.78 (P &amp;lt; .001) in PE and 0.65 (P = .001) in EMDR. Participants in the PE condition (56.6%; odds ratio [OR], 3.41; P = .006) or the EMDR condition (60.0%; OR, 3.92; P &amp;lt; .001) were significantly more likely to achieve loss of diagnosis during treatment than those in the WL condition (27.7%). Participants in the PE condition (28.3%; OR, 5.79; P = .01), but not those in the EMDR condition (16.4%; OR, 2.87; P = .10), were more likely to gain full remission than those in the WL condition (6.4%). Treatment effects were maintained at the 6-month follow-up in PE and EMDR. Similar results were obtained regarding secondary outcomes. There were no differences in severe adverse events between conditions (2 in PE, 1 in EMDR, and 4 in WL). The PE therapy and EMDR therapy showed no difference in any of the outcomes and no difference in participant dropout (24.5%in PE and 20.0%in EMDR, P = .57). &lt;br /&gt;&lt;br /&gt;Conclusions and Relevance:&lt;br /&gt; Standard PE and EMDR protocols are effective, safe, and feasible in patients with PTSD and severe psychotic disorders, including current symptoms. A priori exclusion of individuals with psychosis from evidence-based PTSD treatments may not be justifiable.</text>
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              <elementText elementTextId="406191">
                <text>Journal of the American Medical Association Psychiatry, 72(3), 259-267. doi:10.1001/jamapsychiatry.2014.2637</text>
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                <text>2015</text>
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        <name>Posttraumatic Stress Disorder</name>
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        <name>Prolonged Exposure</name>
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        <name>Psychotic Disorder</name>
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        <name>PTSD</name>
      </tag>
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        <name>Randomized Controlled Trial</name>
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        <name>RCT</name>
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              <text>10595</text>
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              <text>Jonathan Laugharne</text>
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              <text>www.emdr-europe.org</text>
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              <text>Prolonged Exposure, Symposium, Volumetric Change</text>
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              <text>Laugharne, J. (2014, June). Amygdala volumetric change after treatment with EMDR or prolonged exposure. In EMDR neurobiology research symposium (Peter Liebermann, Chair). Symposium presented at the 15th EMDR Europe Association Conference, Edinburgh, Scotland</text>
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              <elementText elementTextId="403833">
                <text>In EMDR neurobiology research symposium (Peter Liebermann, Chair). Symposium presented at the 15th EMDR Europe Association Conference, Edinburgh, Scotland</text>
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                <text>This presentation will outline a recent study in which 20 adult patients with PTSD (CAPS diagnosis) were randomly assigned 12 sessions of either EMDR or Prolonged Exposure (PE). Clinical ratings (CAPS, PCL, Ham A, Ham D) were administered before and after treatment and there was a six week wait list period for each patient prior to therapy. MRI brain scans were administered before and after treatment for both treatment groups. &lt;br&gt;Subsequent analysis of clinical findings, volumetric change in brain structures known to be relevant in fear conditioning, and correlations of brain changes with clinical changes and with number of discrete traumas addressed in therapy will be presented and discussed. Both treatment groups improved significantly on all major clinical measures. Initial structural analysis has focussed on the amygdala and indicates a significant increase in left amygdala following EMDR but not following PE. No correlation was found between improvement in PTSD symptoms and increase in left amygdala. However a correlation was found between number of discrete traumas addressed in therapy and changes in amygdala volume. &lt;br&gt;To our knowledge this is the first study to compare structural brain changes following EMDR and PE and initial analysis of the amygdala changes indicates a possible difference in the biological effects of these two therapies. This difference may be due to more traumas being addressed within 12 EMDR sessions than 12 PE sessions. Further analysis of this rich data set will be undertaken and integrated into the presentation prior to the meeting within the context of the existing literature. </text>
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              <text>10363</text>
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              <text>Ali Maredpour&lt;br /&gt;Farah Naderi&lt;br /&gt;H. M. Mehrabizadeh</text>
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              <text>PE, Posttraumatic Stress Disorder, Prolonged Exposure, PTSD, Veterans</text>
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          <description>emdr_accuracy</description>
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              <text>Maredpour, A., Naderi, F., &amp;amp; Mehrabizadeh, H. M. (2013). [&lt;a href="http://armaghanj.yums.ac.ir/article-1-322-fa.pdf"&gt;Comparing the efficacy of eye movement desensitization and reprocessing therapy with prolonged exposure therapy on the trauma impact symptoms in veterans suffering from chronic PTSD&lt;/a&gt;]. Armaghan Danesh, 5(5 (77)), 356-367. Persian</text>
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              <text>&lt;a href="http://armaghanj.yums.ac.ir/browse.php?a_id=322&amp;amp;sid=1&amp;amp;slc_lang=fa"&gt;http://armaghanj.yums.ac.ir/browse.php?a_id=322&amp;amp;sid=1&amp;amp;slc_lang=fa&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Available PDF:&lt;/strong&gt;&lt;br /&gt;&lt;a href="http://armaghanj.yums.ac.ir/article-1-322-fa.pdf"&gt;http://armaghanj.yums.ac.ir/article-1-322-fa.pdf&lt;/a&gt;</text>
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                <text>&lt;p&gt;مقایسه اثربخشی‌روش درمانی‌حساسیت زدایی‌از طریق حرکات چشم و پردازش مجدد با مواجهه درمانی‌طولانی‌مدت بر نشانه های‌تأثیر واقعه رزمندگان مبتلا به اختلال استرس پس از ضربه مزمن&lt;u&gt;&lt;br /&gt;&lt;br /&gt;&lt;/u&gt;Comparing the efficacy of eye movement desensitization and reprocessing therapy with prolonged exposure therapy on the trauma impact symptoms in veterans suffering from chronic PTSD&lt;/p&gt;</text>
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                <text>Armaghan Danesh, 5(5 (77)), 356-367</text>
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                <text>چکیده زمینه و هدف: اختلال استرس پس از ضربه به عنوان مجموعه علایمی ‌توصیف می‌شوند که پس از آن که شخص رویداد آسیب‌زایی‌ را مشاهده می‌کند، می‌شنود و یا درگیر آن می‌شود، به وجود می‌آیند. هدف این مطالعه مقایسه اثر بخشی‌حساسیت‌زدایی‌از طریق حرکات چشم و پردازش مجدد با مواجهه درمانی ‌طولانی ‌مدت بر نشانه‌های ‌تأثیر واقعه در رزمندگان مبتلا به اختلال استرس پس از ضربه مزمن بود. روش بررسی: در این مطالعه کارآزمایی‌بالینی ‌تعداد 48 نفر از رزمندگانی که در بیمارستان سلمان شهر یاسوج دارای ‌پرونده روانپزشکی ‌بوده و تشخیص اختلال استرس پس از ضربه دریافت کرده بودند، به شیوه تصادفی‌ انتخاب شده و به سه گروه مساوی‌ تقسیم شدند. در دو گروه به عنوان مداخله، روش‌های ‌درمانی ‌حساسیت‌زدایی‌ از طریق حرکات چشم و پردازش مجدد(5جلسه) و مواجهه درمانی ‌طولانی ‌مدت(10جلسه) اعمال شد و بر روی ‌گروه سوم(کنترل) هیچ‌گونه درمانی ‌اعمال نشد. پس از دوره درمان همان آزمون برای‌هر سه گروه اجرا شد. داده‌ها با آزمون آماری تحلیل کوواریانس تک متغیره و آزمون تعقیبی ‌بنفرونی‌تجزیه و تحلیل شدند. یافته‌ها: هر دو روش درمانی‌موجب کاهش معنی‌دار نشانه های ‌تأثیر واقعه شد(001/0 =p). هم‌چنین نتایج حاکی‌از این بود که مواجهه درمانی ‌طولانی ‌مدت در بهبود نشانه‌های ‌تأثیر واقعه مؤثرتر بود. نتیجه‌گیری: فنون مداخله‌ای‌از قبیل روش درمانی‌حساسیت‌زدایی ‌از طریق حرکات چشم و پردازش مجدد و مواجهه در‌مانی‌ طولانی‌ مدت در در‌مان اختلال استرس پس از ضربه کارایی‌ لازم را دارند، اما مواجهه در‌مانی‌طولانی ‌مدت برتری بیشتری‌ دارد. واژه های‌کلیدی: اختلال استرس پس از ضربه، حساسیت زدایی، حرکات چشم، پردازش مجدد، مواجهه درمانی‌طولانی‌مدت&lt;strong&gt;&lt;br /&gt;&lt;br /&gt;Background and Aim:&lt;/strong&gt; &lt;br /&gt;Post-traumatic stress disorder is considered as set of symptoms developed afterward an individual witness, hear or involved. The current research was purposed to compare the efficacy of eye movement desensitization and reprocessing therapy with prolonged exposure therapy on the trauma impact symptoms in veterans suffering from chronic PTSD. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Methods:&lt;/strong&gt;&lt;br /&gt;In this clinical trail research randomly sampled 48 veterans diagnosed with PTSD who had psychiatric records in Salman City Hospital of Yasuj. The subjects devoted in three equal groups: two experimental and one control groups. As intervention procedures the two experimental groups were exposed to eye movement desensitization and reprocessing therapy (5 sessions) and prolonged exposure therapy (10 sessions) respectively. The control group received none. Subsequent to the treatment period the triple groups were post-tested by the prior pre test scales. The data were analyzed by implementing univariate analysis of covariance (ANCOVA) and Bonferroni post hoc test. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; &lt;br /&gt;Both treatment procedures significantly reduced the trauma impact symptoms (p£0.001). The results also indicated that prolonged exposure therapy was more effective concerning the trauma impact symptoms improvement. &lt;br /&gt;&lt;br /&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;br /&gt;Intervention treatment procedures such as eye movement desensitization, reprocessing therapy, and prolonged exposure therapy sustain sufficient efficacy in trauma impact symptoms improvement while prolonged exposure therapy exceeded significantly.</text>
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              <text>Nuwan Jayawickreme &lt;br /&gt;Shawn P. Cahill &lt;br /&gt;David S. Riggs &lt;br /&gt;Sheila A. M. Rauch &lt;br /&gt;Patricia A. Resick &lt;br /&gt;Barbara O. Rothbaum &lt;br /&gt;Edna B. Foa</text>
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                <text>Depression and Anxiety. doi:10.1002/da.22225</text>
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                <text>Background: Prolonged Exposure (PE) therapy is an efficacious treatment for PTSD; despite this, many clinicians do not utilize it due to concerns it could cause patient decompensation. &lt;br /&gt;Method: Data were pooled from four published well-controlled studies of female assault survivors with chronic PTSD (n = 361) who were randomly assigned to PE, waitlist (WL), or another psychotherapy, including cognitive processing therapy (CPT), Eye Movement and Desensitization Reprocessing (EMDR), or the combination of PE plus stress inoculation training (SIT) or PE plus cognitive restructuring. PTSD and depression severity scores were converted to categorical outcomes to evaluate the proportion of participants who showed reliable symptom change (both reliable worsening and reliable improvement). &lt;br /&gt;Results: The majority of participants completing one of the active treatments showed reliable improvement on both PTSD and depression compared to WL. Among treatment participants in general, as well as those who received PE, reliable PTSD worsening was nonexistent and the rate of reliable worsening of depression was low. There were no differences on any outcome measures among treatments. By comparison, participants in WL had higher rates of reliable symptom worsening for both PTSD and depression. Potential alternative explanations were also evaluated. &lt;br /&gt;Conclusions: PE and a number of other empirically supported therapies are efficacious and safe treatments for PTSD, reducing the frequency of which symptom worsening occurs in the absence of treatment.</text>
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                <text>(Doctoral dissertation, University of Georgia). http://athenaeum.libs.uga.edu/xmlui/bitstream/handle/10724/9289/leiner_amy_s_200608_phd.pdf?sequence=1</text>
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                <text>Although there are a number of empirically supported therapies for posttraumatic stress disorder (PTSD), a large minority of those treated fail to respond. Many researchers have attempted to identify variables (participant variables, trauma variables, and treatment variables) that impact PTSD treatment outcome. A review of this literature suggested that there are few, if any, variables that consistently impact PTSD treatment outcome and that few studies are driven by theoretical models of PTSD or its recovery. The cognitive theory of PTSD suggests that a decrease in the avoidance of trauma-related information is required for successful treatment. The current investigation studies the role of a related construct, avoidant coping, in the treatment of rape-related PTSD. Women with PTSD following rape (N = 62) received nine sessions of an empirically supported PTSD treatment (prolonged exposure or eye movement desensitization and reprocessing). PTSD severity was assessed before, during, and after treatment. Avoidant coping was measured before and after treatment. Results indicated that avoidant coping decreased during the course of treatment and that changes in PTSD symptoms were correlated with changes in avoidant coping. Contrary to hypothesis, pretreatment avoidant coping was negatively associated with posttreatment PTSD severity when pretreatment severity was taken into account. Likewise, high levels of pretreatment avoidant coping were associated with a more rapid decline of PTSD symptoms during treatment. Finally, pretreatment avoidant coping did not predict dropout or posttreatment diagnostic status. This study suggests that PE and EMDR are particularly effective at reducing symptom severity for women with initially high levels of avoidant coping.</text>
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              <text>de Bont, P. A. J. M., van Minnen, A., &amp;amp; de Jongh, A. (2013, December). &lt;a href="http://dx.doi.org/10.1016/j.beth.2013.07.002"&gt;Treating PTSD in patients with psychosis: A within-group controlled feasibility study examining the efficacy and safety of evidence-based PE and EMDR protocols.&lt;/a&gt; Behavior Therapy 44(4), 717-730. doi:10.1016/j.beth.2013.07.002</text>
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                <text>The present study uses a within-group controlled design to examine the efficacy and safety of two psychological approaches to posttraumatic stress disorder (PTSD) in 10 patients with a concurrent psychotic disorder. Patients were randomly assigned either to prolonged exposure (PE; N = 5) or eye movement desensitization and reprocessing (EMDR; N = 5). Before, during, and after treatment, a total of 20 weekly assessments of PTSD symptoms, hallucinations, and delusions were carried out. Twelve weekly assessments of adverse events took place during the treatment phase. PTSD diagnosis, level of social functioning, psychosis-prone thinking, and general psychopathologywere assessed pretreatment, posttreatment, and at three-month follow-up. Throughout the treatment, adverse events were monitored at each session. An intention-to-treat analysis of the 10 patients starting treatment showed that the PTSD treatment protocols of PE and EMDR significantly reduced PTSD symptom severity; PE and EMDR were equally effective and safe. Eight of the 10 patients completed the full intervention period. Seven of the 10 patients (70%) no longer met the diagnostic criteria for PTSD at follow-up. No serious adverse events occurred, nor did patients show any worsening of hallucinations, delusions, psychosis proneness, general psychopathology, or social functioning. The results of this feasibility trial suggest that PTSD patients with comorbid psychotic disorders benefit from trauma-focused treatment approaches such as PE and EMDR.</text>
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              <text>&lt;a href="http://dx.doi.org/10.1186/1745-6215-14-151"&gt;http://dx.doi.org/10.1186/1745-6215-14-151&lt;/a&gt;</text>
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              <text>de Bont, P. A., van den Berg, D. P., van der Vleugel, B. M., de Roos, C., Mulder, C. L., Becker, E. S., de Jongh, A., van der Gaag, M., &amp;amp; van Minnen, A. (2013, May). &lt;a href="http://dx.doi.org/10.1186/1745-6215-14-151"&gt;A multi-site single blind clinical study to compare the effects of prolonged exposure, eye movement desensitization and reprocessing and waiting list on patients with a current diagnosis of psychosis and co morbid post traumatic stress disorder: Study protocol for the randomized controlled trial treating trauma in psychosis.&lt;/a&gt; Trials, 14(5), 151. doi:10.1186/1745-6215-14-151</text>
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                <text>A multi-site single blind clinical study to compare the effects of prolonged exposure, eye movement desensitization and reprocessing and waiting list on patients with a current diagnosis of psychosis and co morbid post traumatic stress disorder: Study protocol for the randomized controlled trial treating trauma in psychosis</text>
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                <text>Background: Trauma contributes to psychosis and in psychotic disorders post-traumatic stress disorder (PTSD) is often a comorbid disorder. A problem is that PTSD is underdiagnosed and undertreated in people with psychotic disorders. This study's primary goal is to examine the efficacy and safety of prolonged exposure and eye movement desensitization and reprocessing (EMDR) for PTSD in patients with both psychotic disorders and PTSD, as compared to a waiting list. Secondly, the effects of both treatments are determined on (a) symptoms of psychosis, in particular verbal hallucinations, (b) depression and social performance, and (c) economic costs. Thirdly, goals concern links between trauma exposure and psychotic symptomatology and the prevalence of exposure to traumatic events, and of PTSD. Fourthly predictors, moderators, and mediators for treatment success will be explored. These include cognitions and experiences concerning treatment harm, credibility and burden in both participants and therapists. &lt;br /&gt;&lt;br /&gt;Methods: A short PTSD-screener assesses the possible presence of PTSD in adult patients (21- to 65- years old) with psychotic disorders, while the Clinician Administered PTSD Scale interview will be used for the diagnosis of current PTSD. The M.I.N.I. Plus interview will be used for diagnosing lifetime psychotic disorders and mood disorders with psychotic features. The purpose is to include consenting participants (N = 240) in a multi-site single blind randomized clinical trial. Patients will be allocated to one of three treatment conditions (N = 80 each): prolonged exposure or EMDR (both consisting of eight weekly sessions of 90 minutes each) or a six-month waiting list. All participants are subjected to blind assessments at pre-treatment, twomonths post treatment, and six monthspost treatment. In addition, participants in the experimental conditions will have assessments at mid treatment and at 12 months follow-up. &lt;br /&gt;&lt;br /&gt;Discussion: The results from the post treatment measurement can be considered strong empirical indicators of the safety and effectiveness of prolonged exposure and EMDR. The six-month and twelve-month follow-up data have the potential of reliably providing documentation of the long-term effects of both treatments on the various outcome variables. Data from pre-treatment and midtreatment can be used to reveal possible pathways of change.Trial registration: Current Controlled Trials: ISRCTN79584912.</text>
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              <text>de Bont, P. (2011, August-September). Efficacy and safety of prolonged exposure or EMDR-treatment for PTSD with patients with a vulnerability for psychosis. A multiple baserate N=10 single case design. In Treating PTSD in patients with psychotic disorders. Symposium conducted at the 41st EABCT annual congress, Reykjavk, Iceland</text>
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                <text>Objectives: Untill now, only a small number of studies have investigated the safety and effects of psychological treatment for PTSD in psychotic patients. The main aim of this study was to explore the effects of two psychological, highly manualized, guideline PTSD treatments: EMDR and prolonged exposure. Another important aim was to determine if negative side effects would occur as a result of therapy. Among clinicians fear exists of harming vulnerable patients with confronting therapeutic procedures, thus risking psychotic exacerbation, suicidal behaviour or other adverse events. Methods: In a N=10 single case study design the effects of psychological PTSD treatment were studied in psychiatric patients who suffer from psychoses. Participants were randomly assigned to either EMDR or Prolonged Exposure. Weekly measurements of PTSD and psychotic symptoms prior to, during and after treatment, gave a strong impression of how symptoms respond to treatment. The treatment in both conditions consisted of 12 sessions of 90 minutes. Adverse events were monitored weekly. Before, directly after and 3 months after treatment all subjects were tested more extensively for the variables PTSD and psychosis, and for three secondary outcome measures cognitive style, social functioning and quality of life. Results: The results show that PTSD-treatment can be quite effective for both PTSD and even some of the psychotic symptoms. PTSD symptoms dropped considerably, in a number of cases below the point of still having a PTSD. In some cases treatment helped diminish the occurence of harming voices. Not one patient became psychotic as a result of therapy, not even patients that went through the guided reliving of traumatic psychotic events during Prolonged Exposure. No suicide attempts occured. Occasional minor adverse events with medication occurred, but results taken as a whole the treatments were obviously safe. Conclusion: This study shows that PTSD-treatment in psychotic patients is a serious option, next to medical treatment. It can be done safely, effectively and in a manualized fashion. No information can be derived from this study as to which of the two, Prolonged Exposure or EMDR, can be best applied in specific situations. Both seem to be equal in the limited number of cases.</text>
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                <text>3 CONTROLLED TRIALS FOR PTSD: PE COMPARED TO 1) EMDR; 2) CPT; AND 3) CR Chair: Barbara O. Rothbaum, Emory University School of Medicine, Psychiatry; Discussant: Terence M. Keane, Boston VA Medical Center Three randomized controlled trials treating PTSD in adult female rape victims will be presented: Patti Resick on long-term follow-up of Cognitive Processing Therapy (CPT) vs Prolonged Exposure (PE); Edna Foa on PE alone or with Cognitive Restructuring (CR); and Barbara Rothbaum on PE vs Eye Movement Desensitization and Reprocessing (EMDR) vs waitlist control. &lt;br /&gt;&lt;br /&gt;PROLONGED EXPOSURE VS. EMDR FOR PTSD RAPE VICTIMS Barbara O. Rothbaum, Emory University School of Medicine, Psychiatry; Millie C. Astin, Emory University School of Medicine This controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a notreatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims. In this study, 75 Ss with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per treatment group. All assessments were conducted by an Independent Assessor blind to the treatment condition, and standard measures of PTSD and related symptoms were incorporated. The primary goals of this study were to compare the relative efficacy of EMDR and PE, and compare them to the WAIT control group in treating PTSD in rape victims; to gather information on the differential rate of response to treatment; to develop predictors for response to treatment; and to gather information on the long-term response to treatment for six and twelve months following treatment. The mean age of participants was 34.3 (SD = 11.9) and ranges from 18-63 years. Most participants were Caucasian (69%); 24% are African American, 3% are Latino, and 3% are Other. The majority were single (53%), while 28% were married or living with a partner, and19% were divorced or separated. Treated patients were significantly more improved on all of the PTSD symptom categories as well as by PTSD diagnostic status than the WAIT participants immediately post-treatment. Means and standard deviations of PTSD symptom measures and other symptom measures will be presented and compared for participants who received PE, EMDR, and WAIT at Pre-Treatment and Post-Treatment and 6-month follow-up. &lt;br /&gt;&lt;br /&gt;TWO-YEAR FOLLOW-UP OF A CLINICAL TRIAL COMPARING COGNITIVE PROCESSING THERAPY AND PROLONGED EXPOSURE FOR THE TREATMENT OF PTSD Patricia A. Resick, Pallavi Nishith, University of Missouri-St. Louis The purpose of this presentation will be to describe a telephone follow-up that was conducted two years after the completion of treatment in a controlled trial of cognitive behavioral treatments for PTSD. The treatment study compared cognitive processing therapy (CPT: Resick &amp;amp; Schnicke, 1992), prolonged exposure (PE: Foa et al. 1999) and a delayed treatment waiting-list condition (WL). Following the waiting period, participants in that condition were randomly assigned to one of the two therapy protocols. Participants were 171 female rape survivors who were randomly assigned to one of the three conditions. One hundred twenty-one women completed treatment and at least the post-treatment assessment. The initial study included three and nine month follow-ups. Although it had not been planned originally, we decided to add a two-year follow-up. As of 3/01, we have collected interview data and PTSD Symptom Scale scores (PSS) on 66 women who completed the following groups: CPT (21), PE (25), WL/CPT (9), and WL/PE (11). We have also collected two-year data on 21 women who dropped out after the first assessment, during treatment or after the waiting condition. Findings indicated that, after two years, the women who completed treatment continued to maintain the improvement they evidenced following therapy. There were no significant differences between the two types of treatment at the two-year follow-up although there was a trend for the DL/CPT group to have lower scores than the PE group. When the 66 treated women were collapsed and compared to the women who dropped out, there was no difference between the PSS scores of the two groups at pretreatment but a significant difference at the two-year follow-up, F(1,85)= 6.1, p</text>
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                <text>Predictors for response to treatment in a controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a no-treatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims were examined. In this study, 74 participants with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per group. Independent Assessors blind to the treatment condition administered standard measures of PTSD and related symptoms. Improvement in PTSD, depression, dissociation, and state anxiety was significantly greater in both PE and EMDR group than the WAIT group. PE and EMDR did not differ significantly for change from baseline to either post-treatment or 6-month follow up measurement for any quantitative scale. EMDR subjects with 2 or more comorbid diagnoses, however, improved significantly less than all other active treatment subjects. At post-treatment and 6months, 95% and 94% of PE subjects and 75% and 74% EMDR subjects no longer met DSM-IV PTSD criteria, respectively. At the 6-month follow-up assessment, 78% of those who received PE and 35% of those who received EMDR met criteria for good end state functioning (p=.017).</text>
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                <text>Negative trauma related cognitions have been implicated in the onset and maintenance of PTSD, and often improve with treatment. This controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a no-treatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims. In this study, 75 Ss with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per treatment group. All assessments were conducted by an Independent Assessor blind to the treatment condition. Participants completed the posttraumatic cognitions inventory (PTCI) and measures of PTSD symptomatology at pre- and post- treatment. We will investigate changes in cognitions across active treatment groups, and the extent to which cognitions at baseline predict treatment outcome.</text>
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                <text>Two decades of research demonstrate the efficacy of exposure therapy for posttraumatic stress disorder (PTSD). The efficacy of prolonged exposure (PE), a specific exposure therapy program for PTSD that has been disseminated throughout the world, has been established in many controlled studies using different trauma populations. However, a meta-analysis of the effectiveness of PE for PTSD has not been conducted to date. The purpose of the current paper is to estimate the overall efficacy of PE for PTSD relative to adequate controls. We included all published randomized controlled trials of PE vs. control (wait-list or psychological placebo) for the treatment of PTSD in adolescents or adults. Treatments were classified as PE if they included multiple sessions of imaginal and in vivo exposure and were based on the manualized treatment developed by Foa, Rothbaum, Riggs, and Murdock (1991). Thirteen studies with a total sample size of 675 participants met the final inclusion criteria. The primary analyses showed a large effect for PE versus control on both primary (Hedges's g = 1.08) and secondary (Hedges's g = 0.77) outcome measures. Analyses also revealed medium to large effect sizes for PE at follow-up, both for primary (Hedges's g = 0.68) and secondary (Hedges's g = 0.41) outcome measures. There was no significant difference between PE and other active treatments (CPT, EMDR, CT, and SIT). Effect sizes were not moderated by time since trauma, publication year, dose, study quality, or type of trauma. The average PE-treated patient fared better than 86% of patients in control conditions at post-treatment on PTSD measures. PE is a highly effective treatment for PTSD, resulting in substantial treatment gains that are maintained over time.</text>
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                <text>Since the last edition of this review, there has been an impressive body of new evidence adding to our knowledge of psychological treatments. There have also been two new major reviews covering the complete range of available treatments: the second edition of the guidelines from the International Society for Traumatic Stress Studies (ISTSS) and the US Institute of Medicine's review. The National Institute for Clinical Excellence (NICE) guidelines were published before the last edition of this article, and there are currently no plans to revise them. However, the Australian guidelines build on the NICE guidelines, and provide the most comprehensive and user-friendly clinical guidance currently available. It is fascinating that such major and thorough reviews have arrived at different conclusions. The Institute of Medicine endorses trauma-focused cognitive behavioural therapy (TF-CBT) and prolonged exposure but not eye movement desensitization and reprocessing (EMDR) or drug treatment; NICE endorses TF-CBT and EMDR but not drugs; and the ISTSS guidelines, second edition, endorses drugs, EMDR, and TF-CBT. What is the bewildered therapist to do? Hopefully this review will clarify some of these issues. In truth, the discrepancy arises not because these learned and expert bodies have been perverse, negligent, or biased in their reviewing, but largely because they differ in what they have regarded as a clinically significant difference between two interventions as opposed to a statistical difference.</text>
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                <text>Recent developments in PTSD treatment outcome research: Although cognitive behavior therapy is the treatment of choice for PTSD, there is a need to develop more effective treatments and to determine factors that influence treatment response. This symposium presents four studies that address treatment outcome research. The initial paper provides an overview of treatment predictors from two trials of cognitive processing therapy. The second paper reviews the differential responses to treatment of survivors of terrorist attacks and motor vehicle accidents. The third paper reviews predictors of outcome following EMDR and Prolonged Exposure. The fourth paper overviews a series of studies that have used structural and functional fMRI to identify the neural factors that predict response to CBT and also the impact of CBT on neural functioning. &lt;br /&gt;&lt;br /&gt;Predictors of treatment response for EMDR and prolonged exposure: Predictors for response to treatment in a controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a no-treatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims were examined. In this study, 74 participants with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per group. Independent Assessors blind to the treatment condition administered standard measures of PTSD and related symptoms. Improvement in PTSD, depression, dissociation, and state anxiety was significantly greater in both PE and EMDR group than the WAIT group. PE and EMDR did not differ significantly for change from baseline to either post-treatment or 6-month follow up measurement for any quantitative scale. EMDR subjects with 2 or more comorbid diagnoses, however, improved significantly less than all other active treatment subjects. At post-treatment and 6- months, 95% and 94% of PE subjects and 75% and 74% EMDR subjects no longer met DSM-IV PTSD criteria, respectively. At the 6-month follow-up assessment, 78% of those who received PE and 35% of those who received EMDR met criteria for good end state functioning (p=.017).</text>
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                <text>Prolonged exposure (PE) is an empirically validated treatment for PTSD. However, there remain issues surrounding the optimal length of exposure sessions, the efficacy of prolonged exposure vis-a-vis other behavioral (Foa et al., 1999), cognitive (Resick et al., 2002), cognitive-behavioral (Feske &amp;amp; Chambless, 1995), and EMDR (Ironson et al., 2002) interventions, whether patterns of symptom change differ between PE and cognitive treatments (Nishith, et al., 2002), and those variables that predict significant amounts of variance in treatment outcome (Tarrier, Sommerfield, Pilgrim, &amp;amp; Faragher, 2000). In this presentation, I will discuss the theoretical basis of prolonged exposure therapy, review the comparative outcome literature surrounding prolonged exposure, and summarize empirical research findings with regard to its efficacy and optimal use. Mechanisms of action involved in PE will be discussed with an emphasis on providing a context for the subsequent papers in the Poster.</text>
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                <text>Prolonged exposure and eye movement desensitization and reprocessing (EMDR) are two empirically validated treatments for posttraumatic stress disorder (PTSD). EMDR has several treatment components and findings from dismantling studies indicate that portions of the treatment can be removed without detrimental effects on treatment outcome. The treatment component that has not been tested in a dismantling study is the form of exposure utilized (i.e., “dosed” exposure). This study compared the efficacy and efficiency of prolonged exposure and a dismantled version of EMDR, here labeled “dosed” exposure, for individuals diagnosed with PTSD. The treatments are compared in terms of the participant’s progress, as well as the rate of treatment response. Initial findings from this study will be presented and discussed.</text>
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                <text>During the past years, PTSD treatment competencies raised tremendously due to the development and evaluation in randomized controlled trials. Exposure and cognitive restructuring techniques are basics of a variety of effective psychotherapies. Our symposium discusses challenges, possible shortcomings, implications, and new applications of efficacious techniques (e.g., using the internet). &lt;br /&gt;&lt;br /&gt;First do no harm: Worsening or improvement after prolonged exposure: Despite a substantial body of research accumulated over the 15 years indicating that exposure therapy programs are highly effective in reducing PTSD symptom severity and associated anxiety and depression across a wide range of trauma populations, few therapists utilize this treatment. One reason offered by therapists for not providing this treatment is their concern that exposure therapy may result in symptom worsening among individuals with PTSD (Becker et al., 2003). The purpose of this study was to investigate the frequency of symptoms worsening and symptom improvement following Prolonged Exposure (PE), one particular exposure therapy protocol developed for use in the treatment of PTSD, across five separate treatment studies (Foa et al., 1991, 1999, in preparation; Resick et al., 2002; Rothbaum et al., in preparation) and to compare it with other forms of cognitive behavior therapy (stress inoculation training, cognitive processing therapy, EMDR) and waitlist controls. Preliminary results based on two of the five studies (Foa et al., 1999; in preparation) found worsening of PTSD symptom in less than 1% of participants completing active treatment (N = 162) and 8% of participants completing waitlist (N = 39). PTSD symptom improvement was found in 90% of participants completing cognitive behavior therapy (N = 149) compared to 36% participants completing waitlist.</text>
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                <text>This case discussion will examine the intervention of EMDR (Shapiro, 1989), Prolonged Exposure (Foa, Rothbaum, Riggs &amp;amp; Murdock, 1990), and the Counting Method (Ochberg, 1996) on three adult female patients with PTSD symptoms. A recent treatment outcome study of 40 female trauma victims (Johnson and Lubin, 2001 in press) comparing these three treatments finds that the efficacy of the three treatments is supported and that the element of imaginal exposure may be the critical therapeutic factor. The presentation of these three cases focuses on the issue of client’s treatment preference and client personality traits as factors which may interface with imaginal exposure in treatment efficacy.</text>
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                <text>Three randomized controlled trials treating PTSD in adult female rape victims will be presented: Patti Resick on long-term follow-up of Cognitive Processing Therapy (CPT) vs Prolonged Exposure (PE); Edna Foa on PE alone or with Cognitive Restructuring (CR); and Barbara Rothbaum on PE vs Eye Movement Desensitization and Reprocessing (EMDR) vs waitlist control. &lt;br /&gt;&lt;br /&gt;Prolonged exposure vs. EMDR for PTSD rape victims: This controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a notreatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims. In this study, 75 Ss with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per treatment group. All assessments were conducted by an Independent Assessor blind to the treatment condition, and standard measures of PTSD and related symptoms were incorporated. The primary goals of this study were to compare the relative efficacy of EMDR and PE, and compare them to the WAIT control group in treating PTSD in rape victims; to gather information on the differential rate of response to treatment; to develop predictors for response to treatment; and to gather information on the long-term response to treatment for six and twelve months following treatment. The mean age of participants was 34.3 (SD = 11.9) and ranges from 18-63 years. Most participants were Caucasian (69%); 24% are African American, 3% are Latino, and 3% are Other. The majority were single (53%), while 28% were married or living with a partner, and19% were divorced or separated. Treated patients were significantly more improved on all of the PTSD symptom categories as well as by PTSD diagnostic status than the WAIT participants immediately post-treatment. Means and standard deviations of PTSD symptom measures and other symptom measures will be presented and compared for participants who received PE, EMDR, and WAIT at Pre-Treatment and Post-Treatment and 6-month follow-up. Saturday, Dec. 8 Concurrent Sessions - Saturday, December 8</text>
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                <text>Negative trauma related cognitions have been implicated in the onset and maintenance of PTSD, and often improve with treatment. This controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a no-treatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims. In this study, 75 Ss with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per treatment group. All assessments were conducted by an Independent Assessor blind to the treatment condition. Participants completed the posttraumatic cognitions inventory (PTCI) and measures of PTSD symptomatology at pre- and post- treatment. We will investigate changes in cognitions across active treatment groups, and the extent to which cognitions at baseline predict treatment outcome.</text>
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                <text>(Master's thesis, University of Georgia). Retrieved from https://getd.libs.uga.edu/pdfs/selvig_amy_l_200408_ms/selvig_amy_l_200408_ms.pdf</text>
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                <text>Two therapies for posttraumatic stress disorder (PTSD) have received considerable support in the clinical literature: prolonged imaginal exposure (PE) and eye movement desensitization and reprocessing (EMDR). Although PE is empirically supported, its critics purport that it causes symptom exacerbation. In contrast, proponents of EMDR claim that its response pattern is characterized by rapid decline in symptoms. The current investigation aimed to study and compare the patterns of symptom change during PE and EMDR using hierarchical linear modeling (HLM). HLM avoids many shortcomings inherent in traditional longitudinal analyses by focusing on trajectories of change rather than group means. 62 women with PTSD following rape were randomly assigned to 9 sessions of PE or EMDR. Results indicated that neither group experienced symptom exacerbation nor rapid symptom decline. The patterns of symptom change in the two groups were not significantly different. The strengths and limitations of HLM and the studys design were discussed.</text>
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                <text>This pilot study compared the efficacy of two treatments for PTSD: Eye Movement Desensitization and Reprocessing (EMDR) and Prolonged Exposure (PE). Data were analyzed for 22 patients from a university-based clinic serving the outside community (predominantly rape and crime victims) who completed at least one active session of treatment after three preparatory sessions. Results showed both approaches produced a significant reduction in PTSD and depression symptoms, which were maintained at three-month follow-up. Successful treatment was faster with EMDR as a larger number of people (7 of 10) had a 70% reduction in PTSD symptoms after three active sessions compared to 2 of 12 with PE. EMDR appeared to be better tolerated as the dropout rate was significantly lower in those randomized to EMDR versus PE (0 of 10 vs. 3 of 10). However all patients who remained in treatment with PE had a reduction in PTSD scores. Finally, Subjective Units of Distress (SUDS) ratings decreased significantly during the initial session of EMDR, but changed little during PE. Postsession SUDS were significantly lower for EMDR than for PE. Suggestions for future research are discussed.</text>
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                <text>Langdurige blootstelling aan traumatische herinneringen wordt door velen beschouwd als een noodzakelijk element in de behandeling van posttramatic stress-stoornis (PTSS). Deze bewering wordt ondersteund door de doeltreffendheid van de directe therapeutische blootstelling (DTE), zoals blijkt uit gecontroleerde studies. Omgekeerd is er aanwijzingen dat andere behandelmethoden die geen gebruik maken van langdurige blootstelling wijzen verschijnt even effectief. Bovendien is de effectiviteit van de DTE bemoeilijkt door zowel psychiatrische complicaties en de beperkte compliance van de patiënt als gevolg van problemen met de blootstelling huiswerkopdrachten. In deze paper wordt geconcludeerd dat de DTE is een levensvatbare behandeling voor PTSS, maar het is twijfelachtig of DTE moet worden beschouwd als de 'voorkeursbehandeling' voor PTSS. Steekwoorden: langdurige blootstelling, PTSS, te herzien. &lt;br /&gt;&lt;br /&gt;Prolonged exposure to traumatic memories is considered by many as a necessary element in the treatment of posttramatic stress disorder (PTSD). This claim is supported by the effectiveness of direct therapeutic exposure (DTE), as is evident from controlled outcome studies. Conversely, there is evidence to suggest that other treatment approaches that do not use prolonged exposure appear equally effective. Furthermore, the effectiveness of DTE is complicated by both psychiatric complications and limited patient compliance as a result of difficulties with exposure homework assignments. In this paper, it is concluded that DTE is a viable treatment for PTSD, but it is questionable whether DTE should be considered the 'treatment of choice' for PTSD. Key words: prolonged exposure, PTSD, review.</text>
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