Multisite clinical trial on the ASSYST individual treatment intervention provided to general population with non-recent pathogenic memories

This multisite clinical trial had two objectives: 1) to evaluate the effectiveness, efficacy, and safety of the Acute Stress Syndrome Stabilization Individual (ASSYST-I) treatment intervention in reducing posttraumatic stress disorder (PTSD), depression, and anxiety symptoms in the adult general population with pathogenic memories over three months old, and 2) to explore the correlation coefficient between the PCL-5 total 20 items score and the PCL-5 PTSD Cluster B five intrusion symptoms score with the anxiety and depression variables. A total of 43 adults (39 females and 4 males) met the inclusion criteria and participated in the study. Participants’ ages ranged from 20 to 78 years old (M =47.34 years). Repeated-measures ANOVA were carried out to observe the effect of the intervention on the variables across three time points (Time 1 pretreatment, Time 2 post-treatment and Time 3 follow-up). Results showed significant effects of the ASSYST-I on PTSD symptoms, (F (2, 84), 76.17, p= .001, η2 =.645, β-1=1) ; Intrusion symptoms (F (2, 84), 27.53, p= .000, η2 =.360, β-1=1); Anxiety, (F (2, 84), 28.99, p= .000, η2 =.500, β-1=1) and Depression, (F (2, 84), 14.71, p= .000, η2 =.239, β-1=.99). A positive relationship on Times 2 and 3 between the PCL-5 intrusion symptoms and the anxiety and depression symptoms was also found. Findings provide evidence of the effectiveness, efficacy, and safety of the ASSYST-I in reducing posttraumatic stress, anxiety, and depression symptoms in the general adult population with non-recent pathogenic memories

Nicolle Mainthow 
Maria Cristina Perez 
Amalia Osorio 
Martha Givaudan 
Ignacio Jarero

Mainthow, N., Perez, M. C., Osorio, A., Givaudan, M.,  & Jarero, I. (2022).  Multisite clinical trial on the ASSYST individual treatment intervention provided to general population with non-recent pathogenic memories. Psychology and Behavioral Science International Journal, 19(5), 556024. doi:10.19080/PBSIJ.2022.19.556024