In major depressive disorder (MDD) patients, life stress events represent a risk factor for a severe, early-onset, treatment-resistant and chronic endophenotype. Treatment-resistant depression (TRD) patients who have experienced traumatic events…
Several researches have shown that life stress events, both physical than emotional abuses, are associated with a poorer response and remission outcomes for commonly prescribed antidepressants, earlier illness onset, greater severity of symptoms,…
